Methylene Blue

The Catalyst for Cellular Health, Energy, and Longevity

A legacy of healing and innovation

At Raden Wellness, we integrate methylene blue into our progressive medical practice as a scientifically validated tool to enhance cellular metabolism and overall wellness. Methylene blue acts as a redox mediator in the mitochondrial electron transport chain, facilitating efficient ATP production and reducing oxidative stress by minimizing the generation of reactive oxygen species. Its antioxidant properties help preserve cellular integrity, while emerging research suggests that its mitochondrial-enhancing effects may contribute to improved longevity and cognitive function. By incorporating methylene blue into our treatment protocols, we aim to optimize energy production, support neuroprotection, and promote systemic resilience, aligning with our commitment to advanced, science-driven care.

Patients have experienced a range of noticeable benefits from our methylene blue treatments. Many report increased energy levels and enhanced mental clarity, which help improve focus and reduce fatigue in their daily lives. Clients have also observed improvements in mood stability and stress management, translating into a greater sense of overall vitality and well-being. These positive outcomes reinforce our evidence-based approach, demonstrating how innovative therapies can make a tangible difference in health and quality of life.

Enhanced Mitochondrial Function

Enhanced Mitochondrial Function

Methylene blue acts as a redox mediator in the electron transport chain, improving ATP production and reducing oxidative stress through more efficient electron transfer.

Longevity Enhancement

Longevity Enhancement

Preclinical studies suggest that methylene blue may promote longevity by enhancing mitochondrial efficiency, modulating cellular stress responses, and reducing oxidative damage, which together contribute to a healthier lifespan.

Neuroprotection

Neuroprotection

Its antioxidant properties help protect neurons and maintain mitochondrial integrity, potentially slowing the progression of neurodegenerative conditions.

Clinical Application in Methemoglobinemia

Clinical Application in Methemoglobinemia

As an established treatment, methylene blue converts methemoglobin back to hemoglobin, effectively restoring the blood’s oxygen-carrying capacity in affected patients.

Antioxidant Activity

Antioxidant Activity

By scavenging reactive oxygen species, methylene blue lowers cellular oxidative stress, thereby preserving tissue health and mitigating free radical damage.

Why Methylene Blue?

Methylene Blue is a powerful compound with a wide range of benefits, including cognitive support, mitochondrial enhancement, and improved cellular energy. It can be administered in a few different ways, depending on what’s best for each patient.

Methylene Blue can be administered in many different forms. At Raden, our administration methods include:


IV Therapy (Low-Dose for Optimal Absorption):
We often use IV therapy to deliver Methylene Blue in lower dosages for optimal absorption and effectiveness. This method allows it to bypass the digestive system and get directly into the bloodstream, where it can start working right away.

Paired with EBOO & UVBI
For even greater effects, Methylene Blue can be administered alongside EBOO (Ozone Therapy) with UVBI (Ultraviolet Blood Irradiation). The UV light actually activates Methylene Blue, enhancing its therapeutic benefits for mitochondrial function, detoxification, and immune support.

Oral Supplementation
We also offer Methylene Blue in 20mg capsules, and most patients can take 1-2 capsules for cognitive and cellular benefits. This is a great option for those looking for a convenient way to incorporate it into their routine and this can be used in conjunction with IV administration.

Close up of woman looking relaxed

Who Should Avoid Methylene Blue?

While Methylene Blue is incredibly beneficial for many people, there are some important contraindications to be aware of.

Patients with a deficiency in an enzyme called G6PD (Glucose-6-Phosphate Dehydrogenase) should avoid Methylene Blue. G6PD is crucial for red blood cell function, and without enough of it, Methylene Blue can cause oxidative stress, potentially leading to hemolytic anemia, which is why we screen for this prior to starting

If you’re on medications that affect serotonin levels, such as those listed below, you should not take Methylene Blue, as it can increase serotonin potentially leading to serotonin syndrome, which can be dangerous.

  • SSRIs & SNRIs (commonly prescribed for depression & anxiety)
  • MAO Inhibitors
  • Certain stimulants

How to get started

To make sure Methylene Blue is right for you, we offer a complimentary consultation with a trained medical provider.

This allows us to assess whether you’re a good candidate and determine the best way to incorporate it into your wellness plan. Labs will be drawn to make sure that it’s a safe therapy for each patient.

#1 icon

Book a consultation

#2 icon

Schedule and Analyze your labs

#3 icon

Discuss with a Provider

#4 icon

Begin your Journey

More Benefits of Methylene Blue

Methylene blue, first synthesized in 1876, holds a unique place in medical history as the first pharmaceutical to be included in the United States Pharmacopeia (USP), the gold standard for ensuring the quality and safety of medicines. Initially used as a dye, it was soon recognized for its therapeutic potential, becoming a groundbreaking treatment for malaria in the late 19th century. Since then, it has been employed in a variety of traditional medical applications, many of which continue to this day.

In U.S. hospitals, methylene blue remains a life-saving treatment for conditions such as cyanide poisoning, where it restores normal cellular respiration, and methemoglobinemia, a disorder in which hemoglobin cannot effectively release oxygen to tissues. Methylene blue acts as a reducing agent, converting methemoglobin back to its functional form, enabling efficient oxygen transport.

Disruption of Cellular Respiration

Disruption of Cellular Respiration

Methylene blue interferes with microbial respiration by targeting the electron transport chain within the mitochondria or analogous systems in microorganisms. This disruption prevents the production of ATP (the energy currency of the cell), effectively starving the pathogen of energy.

Antiparasitic Activity

Antiparasitic Activity

Historically, methylene blue was one of the first effective treatments for malaria. It works by interfering with the redox processes of Plasmodium parasites within infected red blood cells, inhibiting their growth and reproduction.

Production of Reactive Oxygen Species (ROS)

Production of Reactive Oxygen Species (ROS)

When exposed to light (photodynamic therapy), methylene blue generates reactive oxygen species, which are highly reactive molecules that damage the microbial cell membrane, proteins, and DNA. This oxidative damage is lethal to pathogens, making it effective against drug-resistant strains.

Biofilm Penetration

Biofilm Penetration

Methylene blue has demonstrated the ability to disrupt biofilms—protective layers produced by bacteria that make infections more resistant to conventional antibiotics. By breaking through these biofilms, methylene blue enhances its antimicrobial efficacy.

Selective Toxicity

Selective Toxicity

Methylene blue selectively accumulates in certain microorganisms, making it particularly effective against pathogens while sparing host cells. For example, its high affinity for acidic environments enables it to target infections in tissues where pH levels are lower due to inflammation.

Immune Modulation

Immune Modulation

Methylene blue has been shown to modulate the immune system by reducing excessive inflammatory responses. It can inhibit the release of pro-inflammatory cytokines, which play a role in tissue damage during infections. By balancing the immune response, methylene blue not only helps control infections but also minimizes collateral damage to healthy tissues, promoting faster recovery.